Clay Webley returns to Florida from the Civil War a hunted man, and his brother, Dan Webley agrees to lead him and his wounded friend, Curtis Parker, through the Everglades to the Gulf of Mexico with Cuba as their final destination. The dying man reveals that Clay has murdered someone. The brothers travel, fighting off alligators and snakes.
A woman lets them stay a while, and romance blooms between her and Dan, while the recovering Clay plots a few schemes of his own. When the Seminoles discover the brothers there, all are forced to flee through the Everglades with the Seminoles in pursuit.
